Abstract P358: Sleepiness and Subclinical Measures of Atherosclerosis in a Bi-racial Cohort: The Bogalusa Heart Study
Introduction: That adverse health outcomes, including atherosclerosis, are associated with sleep disturbance is well-documented; however, evidence from diverse populations on the magnitude of this association, or investigating sleepiness as an outcome, is scarce.
Methods: We examined data from theBogalusa Heart Study, a long-term community-based observational study of a biracial cohort, with first measurements in childhood in 1973. Men and women (n=546) who underwent a measure of carotid intima-media thickness (IMT), calculated as the composite IMT (cIMT), mean of six segments (common and internal carotid, and carotid bifurcation, each left and right), and completed the Epworth Sleepiness Scale (ESS), were included. Multivariable logistic regression was employed to model the association between ordinal self-rated sleepiness and cIMT per standard deviation, adjusted for age, sex, smoking status (at time of IMT measurement), hours of sleep, symptoms of sleep disturbance, and previous heart attack. Based on previous race-specific findings, data were analyzed separately by race.
Results: Of whites (n=356), 59.6% were female and 22.5% were current smokers. Mean (SD) age was 43.1 (4.4) years, and cIMT was 0.6 (0.1) mm. Of African-Americans (n=190), 66.8% were female, 34.7% were current smokers. Mean (SD) age was 42.8 (4.6) years, and cIMT was 0.7 (0.2) mm. Multivariate modeling found a significant race-cIMT interaction term (p=0.04). In stratified analyses, the adjusted odds of abnormal sleepiness (vs. normal sleepiness) were 1.40 times greater (95% CI: 1.04-1.90) per 1-SD increase in cIMT in whites, while among black participants, the odds ratio (95% CI) was 1.01 (0.68-1.50).
Conclusions: There was a significant association between unfavorable subclinical measures of atherosclerosis and excessive daytime sleepiness among white participants.
Author Disclosures: P. Stuchlik: None. B. Pollock: None. W. Chen: None. E. Harville: None. S. Bertisch: None. S. Redline: None. L. Bazzano: None.
- © 2017 by American Heart Association, Inc.