Abstract P356: Association Between Sleep Disturbances and Dyslipidaemia: Systematic Review and Meta-analysis of Prospective Studies
Objectives: To assess the longitudinal evidence of the relationship between sleep disturbances (of quantity and quality) and dyslipidaemia in the general population and to quantify such relationships.
Methods: We performed a systematic search of PubMed and EMBASE (up to July 2016), complemented with manual searches. Studies were included if they were prospective, had sleep quantity and/or quality at baseline and either incident cases of dyslipidaemia or changes in any of the lipid fractions assessed prospectively. Relative risks (95% CIs) were extracted and pooled using a random effect model. Sub-group analyses by lipid type and cumulative meta-analysis by publication date were also performed. Heterogeneity and publication bias were assessed.
Results: 13 studies were identified (4 on quality, 11 on duration). There was heterogeneity in the sleep quality aspects and types of lipids assessed. Classification of sleep duration (per hour/groups) and outcome reporting (changes, risks, differences) also varied widely. In the pooled analysis of sleep duration (6 studies, 16 cohort samples; 30,021 participants; follow-up 2.6-10 years), short sleep was associated with a risk of 1.01 (95% CI: 0.93-1.10) of developing dyslipidaemia, with moderate heterogeneity (I2=56%, p=0.003) andpublication bias (p=0.035). Long sleep was associated with a risk of 0.98 (95% CI: 0.87-1.10) for dyslipidaemia, with heterogeneity (I2=63%, p<0.001) and no publication bias (p=0.248). However, subgroup analyses suggested a trend for higher TChol in short sleepers (1.10; 0.99-1.22; p=0.07) and lower TChol in long sleepers (0.91; 0.81-1.01; p=0.087). Cumulative meta-analysis shows a general trend towards no effect for both short and long sleep duration with dyslipidaemia.
Conclusion: The results do not support a significant relationship between sleep duration and the development of dyslipidaemia. However, heterogeneity in the reporting of both exposure and outcomes and some publication bias limit the interpretation.
Author Disclosures: M. Kruisbrink: None. W. Robertson: None. C. Ji: None. M.A. Miller: None. J.M. Geleijnse: None. F.P. Cappuccio: None.
- © 2017 by American Heart Association, Inc.