Abstract P355: Sleep Duration is Associated With the Metabolic Syndrome Independent of Depression Symptoms The Polish Norwegian Study
Introduction: Short- and long sleep durations have emerged as potential cardiovascular risk factors. Yet, the relation with metabolic syndrome (MetSyn) remains uncertain due to potential residual confounding by depression and comorbidities.
Purpose: To test whether compared to adequate-sleepers, short and/or long- sleepers have higher prevalence of MetSyn, independent of current depression or past psychiatric illnesses.
Methods: Cross-sectional data of 12754 participants, age 45 to 64 years, in an ongoing cohort study, with structured questionnaires and fasting blood samples. We categorized self-reported sleep duration as short (le 5 h), adequate (6-8 h) or long (ge9 h). Metabolic syndrome was defined based on AHA/NHLBI’s criteria. Depression symptoms were ascertained with a culturally-adapted, 7-item Patient Health Questionnaire. We estimated multivariable-adjusted prevalence ratios using Poisson regression models with robust standard error estimates.
Results: Compared to adequate sleepers, both short- and long -sleepers were less likely to be men, to drink alcohol, and be current smokers but more likely to have history of cardiovascular diseases and hypertension. Among short-, adequate and long-sleepers the prevalence of self-reported past psychiatric diseases was 2.28%, 1.59% and 8.50% respectively (p =0.0001) and the prevalence of current antidepressant use was 5.09%, 2.52% and 10.26% respectively (p=<0.0001). Similarly, the prevalence of 5 or more depressive symptoms was 39.36%, 22.09% and 26.98% respectively (p =0.0001). The prevalence of MetSyn among short-, adequate and long-sleepers was 45.38%, 38.12% and 49.56% respectively (p =0.0001). Compared to adequate sleepers, the prevalence of MetSyn remained higher among short-sleepers (PR 1.10, 95% CI 1.01-1.19) and among long-sleepers (PR 1.15, 95%CI 1.02-1.30), after adjusting for age, sex, smoking, alcohol, coffee intake, physical activity, education, non-cardiovascular chronic diseases, past psychiatric diseases, current depression symptoms and current antidepressant drugs use. Difficulties with sleep initiation were not associated with MetSyn. In a subgroup analysis restricted to those with BMI 25-29.9 kg/m2, compared to adequate sleepers, the prevalence of MetSyn remained higher among short-sleepers (PR 1.16, 95% CI 1.02-1.32) and among long-sleepers (PR 1.29, 95%CI 1.04-1.60) after multivariable adjustment.
Conclusion: Both short and long sleep duration are associated with the presence of MetSyn, independent of past psychiatric conditions or current depression symptoms or treatment.
Author Disclosures: G. Vaidean: None. M. Manczuk: None.
- © 2017 by American Heart Association, Inc.