Abstract P330: Childhood Material Deprivation and Self-reported, Physician-diagnosed Myocardial Infarction in a Southern Cohort of Middle-aged African American Men and Women
Introduction: The antecedents of cardiovascular disease occur early in life. However, most studies reporting associations between childhood social conditions and adult myocardial infarction (MI) have been conducted on European and US white populations.
Hypothesis: We hypothesized that adverse childhood social conditions would be associated with increased risk for MI in a Southern cohort of middle-aged African American men and women.
Methods: Multiple logistic regression models were used to investigate sex-specific associations between childhood material deprivation and 13 year incidence of self-reported-physician diagnosed MI among 413 Black men and 754 Black women in the Pitt County (NC) Study. Cohort members were aged 25 to 50 years in 1988, the baseline year, and were re-interviewed in 2001. For this study, childhood was defined as birth to age 13 years; and childhood material deprivation was measured by a composite index of receipt of public assistance, food insecurity, and the lack of household heat, electricity, or plumbing. Odds ratios (OR) of the association between childhood material deprivation and adult MI were estimated after adjusting for both childhood and adulthood socioeconomic position, demographics, lifestyle, co-morbidities and psychosocial factors. For women, menopausal status was also controlled.
Results: Men exposed to 1-2 types of childhood material deprivation had 38% lower odds of MI than men unexposed to such deprivation during childhood, OR = 0.62; 95%CI: (0.41, 0.92). However, men exposed to 3+ types of material deprivation during childhood were 3 times more likely to report a physician-diagnosed heart attack than men who were unexposed, OR = 3.07; 95%CI: (1.79, 5.29). No difference in 13 year MI risk was observed between women exposed to 1-2 types of childhood material deprivation and women who were unexposed, OR = 1.23; 95%CI: (0.70, 2.16). However, women exposed to 3+ types of early-life material deprivation were 5 times more likely to report a physician-diagnosed MI compared to women who were unexposed, OR = 5.20; 95%CI: (2.58, 10.48).
Conclusions: Our findings suggest that early childhood is a sensitive period wherein severe socioeconomic disadvantage may trigger, or exacerbate, biological processes that increase risk of MI, by middle age, in African American men and women.
Author Disclosures: D.S. Barrington: None. S.A. James: None.
- © 2017 by American Heart Association, Inc.