Abstract P292: Re-evaluation of the Relations of Egg Consumption to Serum Total Cholesterol, Cause-specific and All-cause Mortality
Background: We previously reported that egg consumption was related to age-adjusted serum total cholesterol (TCH), and all-cause mortality in the 1-2-eggs/wk group was significantly lower than that in the 1-egg/d group in women, whereas no such relations were noted in men, using 14 year follow-up of NIPPON DATA80. Re-evaluation of these relations in a different cohort is needed.
Methods: We analyzed the relations of egg consumption to serum total cholesterol (TCH) and cause-specific and all-cause mortality by using the NIPPON DATA90 database with a 15-year follow-up. At the baseline in 1990, a nutritional survey was performed by using the food-frequency method, and data were collected on study participants, ages 30 years and over, from randomly selected areas in Japan. We followed 4,799 female participants without history of stroke or myocardial infarction (mean age 52.8 y) for 15 years.
Results: The participants were categorized into 5 egg consumption groups on the basis of their responses to a questionnaire (seldom, 1-2/wk, 1/2 d, 1/d, and ≥2/d). There were 218, 1507, 1622, 1409, and 43 women in each of the 5 groups, respectively. Age-adjusted TCH was not related to egg consumption (206.4, 206.3, 207.0, 207.7, and 203.8 mg/dL in the 5 egg consumption categories, respectively, P=0.737, analysis of covariance). There were 199 cardiovascular disease (CVD), 221 cancer, and 642 all-cause mortality during follow-up. Cox analysis, adjusted for confounding factors, found that all-cause and cancer mortality in the ≥2/d group were significantly higher than that in the 1-egg/d group (HR in the ≥2/d vs the 1-egg/d group: all-cause, 1.88 [95%CI: 1.12-3.16]; cancer, 2.77 [1.32-5.80]), and that cancer mortality in the 1-2-eggs/wk group was significantly lower than that in the 1-egg/d group (0.70 [0.50-0.99]). Egg consumption was not associated with CVD mortality.
Conclusions: Loss of the relation of egg consumption to TCH might be due to that hypercholesterolemic individuals avoided eating eggs. Positive association of egg consumption with cancer and all-cause mortality needs further evaluation, and it may indicate that limiting egg consumption has some health benefits, at least in women in Japan.
Author Disclosures: Y. Nakamura: None. T. Okamura: None. Y. Kita: None. K. Miura: None. A. Okayama: None. H. Ueshima: None.
- © 2017 by American Heart Association, Inc.