Abstract P277: Orthostatic Hypotension Predicts Arterial Stiffness Later in Life
Arterial stiffness is a major risk factor for myocardial infarction, stroke, end-stage renal disease and other cardiovascular diseases. It is now recognized that measures of central arterial function are better and more useful predictors of vascular health outcomes than measures of traditional blood pressure, and pulse wave velocity (PWV) is now considered the gold standard non-invasive method for measuring aortic stiffness. The aim of the present study was to test the hypothesis that orthostatic changes (hypo- or hypertension) may be related to arterial stiffness, as inferred by PWV over a five year period, with consideration given to other cardiovascular risk factors, lifestyle and PWV-related variables. Orthostatic hypotension was defined as a fall in systolic blood pressure of 20 mm Hg or more, or in diastolic blood pressure of 10 mm Hg or more, and orthostatic hypertension as a rise in systolic blood pressure or 20 mm Hg or more. The majorprospective analysis was undertaken on 503 community-dwelling participants (mean age 61 years, 60% women) from the Maine-Syracuse Longitudinal Study (MSLS). At baseline, the prevalence of orthostatic hypotension and hypertension was 3.9% and 4.9%, respectively. Orthostatic blood pressure variables were related to PWV, after adjustment for demographic, cardiovascular, lifestyle and PWV-related factors. Arterial stiffness was significantly greater in those with orthostatic hypotension (12.1 ± 0.56 m/s) than in those without (10.5± 0.11 m/s), measured up to five years later, with full multivariate adjustment. Orthostatic hypertension was not associated with arterial stiffness. In conclusion, we found that orthostatic hypotension predicts arterial stiffness later in life.
Author Disclosures: G. Crichton: None. M. Elias: None.
- © 2017 by American Heart Association, Inc.