Abstract P234: The Relationship Between Polyphenols and Body Composition within the Hispanic Community Health Study/Study of Latinos Nutrition and Activity Study
Background: Polyphenols have antioxidant properties that may protect against chronic disease.Epidemiological evidence regarding potential impact on body composition and obesity is limited, particularly among Hispanics/Latinos who are disproportionately prone to obesity.
Hypothesis: Polyphenols are associated with lower percent body fat (%BF) and prevalence of obesity, with moderate intra-class correlations between repeated measures.
Methods: Participants were 442 adults from SOLNAS aged 18-74y. Doubly labeled water, a recovery biomarker, estimated Total Energy Expenditure . Polyphenol excretion from 24-hour urine samples was assessed for enterolactone, enterodiol, resveratrol, daidzein, urolithin A, naringenin, hesperetin, and quercetin (nmol/liter). Measures were repeated in a subsample (N=90) to provide a reliability measure. Anthropometric measures were obtained by trained personnel, and %BF was measured by 18O dilution. Diet was assessed using two 24-hour recalls. Linear regression models were used to evaluate the multivariable associations between body composition and polyphenols. Spearman correlations between BMI and %BF with polyphenols and intra-class correlation coefficients (ICCs) between repeated polyphenol measures were computed.
Results: Resveratrol and %BF were weakly correlated (r=-0.11, p=0.02), but 69% of urinary resveratrol levels were below detectable limits. Hesperetin was associated with a 12% lower odds of obesity in models unadjusted for TEE (Table 1), while enterolactone was associated with 16% higher odds in fully-adjusted models. Repeated polyphenol measures were moderately correlated (ICCs:0.11-0.65). Urinary polyphenols and their main food sources were weakly correlated (r=0.10-0.17, p<0.03).
Conclusions: Hesperetin and quercetin were inversely while enterolactone was positively associated with obesity. Findings are indicative of an immigrant group in transition. Repeated measures of urinary polyphenols could help clarify impact on obesity.
Author Disclosures: N. Makarem: None. Y. Mossavar-Rahmani: None. D. Sotres-Alvarez: None. S. Hua: None. W.W. Wong: None. L. Van Horn: None. M.L. Daviglus: None. A. Franke: None. J.M. Beasley:None.
- © 2017 by American Heart Association, Inc.