Abstract P208: The Joint Association of Low Vitamin D and Vitamin K Status with Blood Pressure and Hypertension
Introduction: Low vitamin D and vitamin K status are both associated with cardiovascular risk. New evidence from experimental studies on bone health suggest an interaction between vitamin D and K, however a joint association with vascular health outcomes is largely unknown.
Hypothesis: We assessed the hypothesis that the combination of low vitamin D and low vitamin K status is associated with higher systolic and diastolic blood pressure in 402 participants and with incident hypertension in 231 participants free of hypertension at baseline.
Methods: We used data from a subsample of the Longitudinal Aging Study Amsterdam (LASA), a population-based cohort of Dutch participants 55-65 years. Vitamin D and K status were assessed by measuring 25-hydroxyvitamin D [25(OH)D] and dephosphorylated uncarboxylated matrix gla protein (dp-ucMGP). High dp-ucMGP is indicative of a low vitamin K status. Generalized estimating equation and Cox proportional hazard models were used for the association of vitamin D and vitamin K status with blood pressure and incident hypertension (systolic blood pressure ≥140 or diastolic blood pressure ≥90 mmHg or using anti-hypertensive medication).
Results: During a median follow-up of 6.4 years, 62% of the participants (n=143) developed hypertension. Vitamin D and vitamin K status were categorized in groups: 25(OH)D <50/≥50 mmol/L and median dp-ucMGP <323/≥323pmol/L. The combination of low 25(OH)D <50 nmol/L and high dp-ucMGP ≥323 pmol/L was associated with increased systolic 4.8 mmHg (95% CI 0.1-9.5) and diastolic 3.1 mmHg (0.5-5.7) blood pressure compared to 25(OH)D ≥50 mmol/L and dp-ucMGP <323 pmol/L, after adjusting for age and sex, BMI, alcohol consumption, smoking, education, season of blood collection, total cholesterol and estimated glomerular filtration rate. A similar trend was seen for incident hypertension HR:1.62 (0.96-2.73).
Conclusions: The combination of low vitamin D and K status was associated with increased blood pressure and might play a role in the development of hypertension.
Author Disclosures: H. van Ballegooijen: None. I.A. Brouwer: None. M. Visser: None. N. van Schoor: None. J.W. Beulens: None.
- © 2017 by American Heart Association, Inc.