Abstract P166: Multimorbidity and Risk of Mortality in China: Results From the Chinese Electronic Health Records Research in Yinzhou (CHERRY) Study
Introduction: The prevalence of multimorbidity is increasing in developed countries, while corresponding research in Chinese population is limited.
Methods: A population-based cohort in Yinzhou located in an eastern coastal area of China (961,008 adults ≥18 years in 2009; latest mortality follow-up: Nov 2015; 22,637 deaths; 6.53 million person-years at risk) was assembled by linking epidemiological surveys, electronic records for chronic disease management, health administrative and medical records databases. Multimorbidity was defined as the presence of two or more following disorders: hypertension, diabetes, cardiovascular disease or cancer. History of selected diseases was extracted from the electronic records for chronic disease management. Follow-up on fatal events is achieved through records linkage to the regional system of death surveillance.
Results: Overall age- and sex-standardized prevalence of one, two or ≥3 disorders were 16.16% (16.09% - 16.23%), 4.11% (4.07% - 4.15%) and0.36% (0.35% - 0.38%) respectively, whereas 41.73%, 14.41% and 1.67% were observed in people aged 60 years and older. The all-cause mortality rate adjusted to the age of 60 was 4.77 per 1000 person-years. Comparing to people without any selected diseases, the age- and sexadjusted HRs for all-cause mortality were 1.17 (1.14, 1.21) in those with one disorder, 1.78 (1.72, 1.86) in those with two morbidities, and 2.97 (2.76, 3.19) in those with ≥3 morbidities. The HRs in those with multimorbidites were higher in younger people and were heterogeneous among different combinations of multimorbidites. Population-attributable fractions (PAF) for all-cause mortality due to one, two or ≥3 disorders were 2.63%, 3.04% and 0.67% respectively (1.28%, 7.69% and 2.34% in people aged 60 years and older).
Conclusions: The CHERRY study can serve as a valuable big data resource for scientific research in China. Multimorbidity is becoming acommon condition in Chinese population, especially in older population, and is associated with high mortality. A complementary strategy is required for population health interventions.
Author Disclosures: H. Lin: None. D. Zhang: None. P. Shen: None. Z. Xu: None. Y. Si: None. X. Tang: None. P. Gao: None.
- © 2017 by American Heart Association, Inc.