Abstract P141: Biological and Socioeconomic Determinants of Dysglycaemia in Canadian Youth
Background: Population-based rates of prediabetes or dysglycaemia (i.e. elevated A1C) among low-risk youth are not well described. Moreover, the biological and socioeconomic determinants of an elevated A1C in youth remain poorly understood.
Methods: Youth aged 6-19 years who participated in the first (2007-2009) or second (2009-2011) cycles of the Canadian Health Measures Survey (CHMS) were included in our analyses. The primary outcome, dysglycaemia was defined using A1C guidelines established by the American Diabetes Association (ADA: 5.7%-6.4%) and Canadian Diabetes Association (CDA: 6.0%-6.4%). Various biological and socioeconomic determinants were compared between healthy and dysglycaemic youth using two sample t-tests and χ2 tests (Table 1). Multivariable logistic regression was used to calculate adjusted odds ratios for dysglycaemia. Age stratified regression was performed to adjust for physical activity. All analyses were unweighted.
Results: Of the 3449 youth studied, 785 (22.8%) and 179 (5.2%) displayed dysglycaemia according to ADA and CDA definitions, respectively. Youth with dysglycaemia (ADA definition) were more likely to be male (55.4 v 50.6%, p=0.02), non-white (24.8 v 14.6%, p<0.001) and obese (16.2 v 10.8%, p<0.001). Dysglycaemia in youth was more common in those living in households with middle income adequacy (32.6 v 26.8%, p=0.006) and lower levels of parental education (high school or less, 15 vs 11.4%, p=0.007). Similar associations were found using CDA definition. In the adjusted logistic regression model (age ≥12y), significant predictors were age, race, income adequacy, geographic region, obesity (OR=1.60, 95% CI: 1.08-2.35) and physical activity (monthly frequency of activity longer than 15 minutes, OR=0.97, 95% CI: 0.95-0.99).
Conclusion: Nearly 1 of every 5 youth in Canada are at risk for type 2 diabetes, based on early elevated A1C. Elevated A1C in youth is associated with social determinants of health and some lifestyle factors and both should be addressed in prevention efforts.
Author Disclosures: A. Feely: None. C. Rodd: None. A. Dart: None. A. Sharma: None. J. McGavock: E. Honoraria; Modest; Medtronic.
- © 2017 by American Heart Association, Inc.