Abstract P138: Asthma and Left Ventricular Mass in Young Adults: the Bogalusa Heart Study
Background: A history of asthma from childhood has been related to various risk factors affecting left ventricular (LV) remodeling; however, no prospective study has analyzed the impact of asthma on markers of LV remodeling.
Methods: Prospective analyses were performed among 1177 Bogalusa Heart Study participants (average age at follow-up: 36.3±8.3), with a baseline history of self-reported asthma collected since childhood (mean first diagnosed age: 25.2±10.3). LV mass was assessed using 2-dimensional guided M-mode echocardiography, and indexed for body height (m2.7) as LV mass index (LVMI, g/m2.7). A multivariate linear mixed model was fitted for the repeated measures.
Results: After an average of 9.1 years follow-up, participants with a history of asthma showed significantly greater LV mass (166.9 vs. 156.3, p=0.007) and LVMI (40.1 vs. 37.1, p=0.002) than those without asthma, with adjustment for age, gender, race, smoking status, antihypertensive medicine, heart rate and systolic blood pressure (SBP) at follow-up. Also, we found significant interactions between SBP and asthma on LV mass and LVMI (p for interaction= 0.008 and 0.006). The associations between asthma and LV measures appeared to be stronger among prehypertensive participants (SBP≥130 mm/Hg) compared with those with normal SBP (<130 mm/Hg) [regression coefficient: 26.12 vs. -0.79 for LV mass; and 6.75 vs. 0.29 for LVMI].
Conclusions: Our findings indicate that a history of asthma is associated with higher LV mass, and such association is stronger among individuals with prehypertension.
Author Disclosures: D. Sun: None. T. Wang: None. Y. Heianza: None. J. Lv: None. F. Rabito: None. T. Kelly: None. S. Li: None. J. He: None. L. Bazzano: None. W. Chen: None. L. Qi: None.
- © 2017 by American Heart Association, Inc.