Abstract P063: The Overall Burden of Pre-diabetes and Diabetes in Luxembourg: Resembling the US Scenario
Background: Type 2 diabetes is an increasingly prevalent disease affecting 422 million adults in the world in 2014. Its surveillance and timely detection are necessary steps to control associated comorbidities. While several national population-based studies in Western European countries have reported diabetes prevalence and associated risk factors, there has been a limited focus on pre-diabetes. Therefore, the aim of this study was to determine the prevalence and associated risk factors of pre-diabetes and diabetes in the general adult population of Luxembourg.
Methods: Within the framework of the Luxembourg European Health Examination Survey (EHES-LUX), a cross-sectional study was conducted between 2013 and 2015, based on a random sample from the general population. 1451 residents of Luxembourg (25-64 years old) were included. Diabetes, unknown diabetes and pre-diabetes participants were defined by glycemia measures, self-reported medication over the last 2 weeks and medical diagnosis. Logistic regressions analyses adjusted on sex, age and region were performed to determine the factors associated with pre-diabetes and diabetes. Multivariable-adjusted odds ratios (MVOR) were calculated. The explanatory variables were biological and anthropometric indicators as well as patient’s socio-economic status and lifestyle. We considered P < 0.05 to be statistically significant.
Results: The national standardized prevalence of pre-diabetes and diabetes in Luxembourg was 23.7% and 5.8% respectively. We observed a deleterious association between diabetes status and age (MVOR=1.05 [1.01-1.09]), family history of diabetes (MVOR=3.25 [1.95-5.40]), abdominal obesity (MVOR=2.62 [1.53-4.49]), hypertension (MVOR=3.20 [1.78-5.73]), and triglycerides (MVOR=1.08 [1.05-1.12]) whereas a protective association occurred with total cholesterol (MVOR=0.84 [0.78-0.92]). Moreover, we observed a deleterious association between pre-diabetes status and age (MVOR=1.04 [1.02-1.06]), male sex (MVOR=1.83 [1.30-2.58]), family history of diabetes (MVOR=1.52 [1.13-2.05]) and abdominal obesity (MVOR=1.44 [1.06-1.96]) whereas a protective association occurred with second generation immigrants (MVOR=0.63 [0.41-0.98]) and serum HDL (MVOR=0.83 [0.72-0.95]).
Conclusions: In Luxembourg, an unexpectedly high number of adults may be affected by pre-diabetes and unknown diabetes. These values are close to US prevalence estimates, and are certainly among the highest values in Western European countries, emphasizing even more that these conditions should be prioritized as a public health threat for the country, requesting measures for improved detection and surveillance, especially in the primary care setting.
Author Disclosures: S. Stranges: None. M. Ruiz-Castell: None. C. De Beaufort: None. J. Barré: None. N. De Rekeneire: None. G. Michel: None. R.P. Donahue: None. A. Kuemmerle: None. V. Bocquet: None.
- © 2017 by American Heart Association, Inc.