Abstract P043: Higher Levels of CRP and IL-6 are Associated With Femoral Artery Plaque Presence, but Not Plaque Characteristics: The San Diego Population Study (SDPS)
Introduction: The potential involvement of c-reactive protein (CRP), interleukin (IL)-6 and intracellular adhesion molecule (ICAM)-1 in the destabilization, erosion, or rupture of arterial plaque, particularly plaques in the lower extremity arteries is not well-established. Thus, we sought to determine whether circulating levels of CRP, IL-6, and ICAM-1 were associated with the presence, burden, and characteristics of femoral artery plaques.
Methods: The San Diego Population Study is a prospective, population-based, multi-ethnic cohort of 1103 men and women averaged age 70 at a follow up exam taking place from 2007-11. At this exam, B-mode ultrasound was used to measure plaque presence, burden, and characteristics, including total plaque area (TPA), mean grey-scale median (GSM), and presence of calcification. Plaques were assessed in the left and right superficial and common femoral arteries. Plaque presence was defined as any plaque in any arterial segment, while plaque burden was total number of plaques summed over all four segments. Circulating CRP, ICAM-1, and IL-6 were also measured at this exam. Associations of CRP, IL-6, and ICAM-1 with plaque presence and burden were assessed using logistic and zero-inflated Poisson regression, respectively. Among those with plaque, linear and logistic regression were used to assess associations of the biomarkers with plaque characteristics. All models adjusted for age, sex, race/ethnicity, BMI, BP, statin use, smoking status, diabetes, peripheral artery disease, and chronic kidney disease.
Results: Higher circulating CRP was significantly associated with plaque presence with participants in the highest quartile of CRP having 1.8 times higher odds of having femoral plaque compared to those in the lowest quartile. Participants in the highest quartiles of CRP and IL-6 were significantly more likely to have greater plaque burden compared to those in the lowest quartiles (CRP OR=1.64, 95% CI=1.09-2.44; IL-6 OR=1.65, 95%CI=1.06-2.55). No associations were observed between circulating biomarkers and plaque characteristics, including TPA, GSM, or calcification.
Conclusions: Higher levels of circulating CRP and IL-6 are associated with greater plaque burden in the femoral arteries of participants in the SDPS; however, these biomarkers do not appear to be associated with characteristics of femoral artery plaques. These results are consistent with findings in the carotid and coronary arteries.
Author Disclosures: N. Suder: None. E. Barinas-Mitchell: None. M. Allison: None. M. Criqui: None. J. Ix: None. N. Jenny: None. C. Wassel: None.
- © 2017 by American Heart Association, Inc.