Abstract P039: Lipid Rich Plaque by Coronary CT Angiography Associates With Cholesterol Efflux Capacity Independent of Traditional Cardiovascular Risk Factors in Those at Risk for Myocardial Infarction
Introduction: Cholesterol efflux capacity (CEC), a measure of high density lipoprotein (HDL) function, has been shown to be associated with future cardiovascular (CV) events. Lipid rich plaque is associated with higher plaque rupture and future CV events, and can be readily phenotyped by coronary CT angiography (CCTA). Whether CEC associates with lipid rich plaque is not known.
Hypothesis: We hypothesize that CEC associates with lipid rich plaque in those at risk for myocardial infarction (MI).
Methods: Consecutively recruited patients (N=94) underwent CCTA (Toshiba 320 slice) to assess plaque burden within the coronary arteries by QAngio CT (Medis, The Netherlands); history was obtained and statin use was recorded. CEC was measured using an ex vivo validated assay.
Results: The study population mean age was 61 and had normal cholesterol, HDL, low density lipoprotein (LDL), and triglyceride levels (Table 1). CEC was 1.03 ± 0.17 while total plaque and lipid rich plaque were 1.05 (0.79-1.37) mm2 and 1.00 (0.77-1.33) mm2, respectively. Lipid rich plaque inversely associated with CEC beyond adjustment for age, gender, systolic blood pressure, statin treatment, total cholesterol, LDL, and HDL (β= -0.18, p=0.002).
Conclusion: CEC associated with lipid rich plaque independent of CV risk factors to provide additional risk stratification in those at risk for MI and early atherogenesis.
Clinical Implications: My study will help cardiovascular clinicians to better understand that HDL function may capture additional CV risk in those at risk for future MI.
Author Disclosures: J.H. Chung: None. A.K. Dey: None. A. Chaturvedi: None. J.P. Rivers: None. J.B. Lerman: None. C.L. Harrington: None. M. Ahlman: None. M.P. Playford: None. S.M. Gordon: None. A.A. Joshi: None. A.T. Remaley: None. M. Chen: None. D.A. Bluemke: None. N.N. Mehta: None.
- © 2017 by American Heart Association, Inc.