Abstract MP072: Low Vitamin K Status is Prospectively Associated With Greater Left Ventricular Mass
Introduction: Vitamin K is a fat soluble vitamin and is required as a co-factor for the carboxylation of several proteins. Matrix gla-protein (MGP) requires vitamin K for its activation and is a potent vascular calcification inhibitor. High concentrations of dephosphorylated uncarboxylated MGP (dp-ucMGP) -a functional marker of vitamin K status- are associated with increased coronary artery calcification and cardiovascular disease, but the underlying mechanism remains unclear.
Hypothesis: We hypothesized that higher levels of dp-ucMGP (indicating low vitamin K status) are associated with unfavorable measures of cardiac structure and function after 7 years of follow-up.
Methods: In the Hoorn Study, a population-based cohort, 598 participants mean age 70.1±6.6 years, 51% female, had physical examinations in 2000-2001 (baseline for the current analyses), of whom 249 had a follow-up in 2007-2009. Plasma dp-ucMGP levels were measured with ELISA in baseline samples. We studied the cross-sectional and prospective association of dp-ucMGP with echocardiographic measures of left ventricular mass index (LVMI), ejection fraction and left atrium volume index using linear regression analyses, adjusted for age, sex, BMI, education, smoking, type 2 diabetes and LDL-cholesterol.
Results: Median plasma dp-ucMGP was 567 (392-701) pmol/l and mean follow-up time was 7.0±0.7 year. Cross-sectionally, the highest dp-ucMGP quartile ≥701 pmol/l compared to the lowest quartile <392 pmol/l was associated with a 2.7 g/m2.7 (95% CI -0.8, 6.2) greater LVMI. In the prospective analysis adjusting for baseline LVMI and follow-up time, the association was more pronounced and became significant 6.5 g/m2.7 (95% CI 1.5, 11.4). This result was confirmed by the continuous association (Figure 1). No significant associations were observed between dp-ucMGP with ejection fraction and left atrium volume index.
Conclusion: In conclusion, these results suggest that a low vitamin K status is prospectively associated with a greater LVMI.
Author Disclosures: H. van Ballegooijen: None. I.A. Brouwer: None. M. Visser: None. G. Nijpels: None. J.M. Dekker: None. R.J. Rennenberg: None. C. Vermeer: None. C.D.A. Stehouwer: None. J.W. Beulens: None.
- © 2017 by American Heart Association, Inc.