Abstract MP034: Muscle strength and Short-term Risk of Cardiovascular Outcomes in Community-dwelling Older Adults: The Atherosclerosis Risk in Communities (ARIC) Study
Background: Muscle weakness has been shown to predict mortality in older adults. However, its contribution to different cardiovascular disease (CVD) subtypes is not well known.
Methods: Among 5,484 participants (age 67-91 years) in the ARIC Study at visit 5 (2011-13), we quantified the associations of grip strength (measured by Jamar Hydraulic Hand Dynamometer) with the risk of coronary heart disease (CHD including myocardial infarction or coronary death), stroke, and heart failure (HF) using Cox models.
Results: Over a median follow-up of 1.7 years, there were 119 cases of CHD, 47 cases of stroke, and 168 cases of HF. In crude models, the lowest sex-specific quartile of grip strength demonstrated significantly higher risk of CHD and HF compared to the highest quartile (Table). After accounting for potential confounders such as diabetes, body mass index, and blood pressure, the significant association was only observed for HF (HR 2.09 [95% CI 1.25-3.50] between the lowest vs. highest quartile).
Conclusion: Weaker muscle strength was significantly associated with CVD risk in community-dwelling older adults, but its independent association was most evident for HF. Our results suggest the pathophysiological link between skeletal muscle function and HF as well as potential usefulness of grip strength to classify HF risk in older adults.
Author Disclosures: K. Matsushita: None. N. Ding: None. S.H. Ballew: None. P. Palta: None. J.A. Schrack: None. B.G. Windham: None. J. Coresh: None.
- © 2017 by American Heart Association, Inc.