Abstract MP013: Diet High in Sweets and Sugar-sweetened Beverages But Low in Fruits and Vegetables is Associated With Pro-inflammatory Adipokine Profile in Mexican Americans at Risk For Diabetes
Background: High consumption of sweets and sugar-sweetened beverages is associated with obesity, insulin resistance and cardiovascular disease. Pro- and anti-inflammatory adipokines may mediate the relationship between dietary intake and poor metabolic profile. However, studies investigating the association between diet and adipokines are scant and often restricted to one or two biomarkers.
Study design and methods: Subjects were participants of BetaGene, a study of obesity, insulin resistance and β-cell dysfunction in Mexican Americans (n=1,128, 73% female, age 34.6±8.0, BMI 29.5±5.9). Adiponectin, IL-1β, IL-6, IL-1Ra, leptin, lipocalin, MCP-1, resistin and TNF-α were assayed using Millipore multiplex kits with magnetic bead panels; apelin, CRP, DPP-IV, visfatin, SFRP4 and SFRP5 were measured with ELISA. Dietary intake was assessed by 12-mo recall (126-item Harvard-FFQ). Joint multivariate associations between levels of adipokines and food group consumed (grams/day) were analyzed using canonical correlation after adjustment for age, sex and energy intake.
Results: Median (IQR) energy intake was 2.27 (1.75,2.85) Mcal/day. While 55% of total intake was accounted for by carbohydrates, 24% was due to sugar. A total of 37% of the shared variation between diet and adipokines was explained by the top linear association between the two. The top dietary component (Figure 1) was most represented by sugar-sweetened beverages (SSB, loading coefficient ρ=0.55), sweets (ρ=0.53), fruits (ρ=-0.47), fruit juices (ρ=-0.34), and vegetables (ρ=-0.30), while the adipokine component was most represented by leptin (ρ=0.63), CRP (ρ=0.56), and MCP-1 (ρ=0.47).
Conclusions: Diets high in sweets and sugar-sweetened beverage but low in fruits and vegetables contribute to a pro-inflammatory profile characterized by high leptin, CRP and MCP-1, which in turn is associated with poor metabolic profile in Mexican Americans at risk for type 2 diabetes.
Author Disclosures: C. Koebnick: None. M. Black: None. J. Wu: None. Y. Shu: None. T. Buchanan: None. A. Xiang: None.
- © 2017 by American Heart Association, Inc.