Response by Bailey to Letter Regarding Article, “Nitrite and S-Nitrosohemoglobin Exchange Across the Human Cerebral and Femoral Circulation: Relationship to Basal and Exercise Blood Flow Responses to Hypoxia”
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Our human physiological study1 was originally designed to measure changes in local arterial to venous concentration gradients of nitrite (), S-nitrosohemoglobin (SNO-Hb), and iron nitrosylhemoglobin (HbNO) in response to exercise and hypoxia. Metabolite and O2 transport to the peripheral tissues yield artery-to-vein gradients; such gradients have formed the fundamental basis for arguments that red blood cell SNO-Hb or reduction via deoxygenated hemoglobin contributes to hypoxic vasodilation, thereby coupling O2 delivery to metabolic demand.2,3
Although we do not directly test the endocrine signaling actions of these nitric oxide (NO) metabolites, a limitation we duly acknowledge, we nonetheless measure the gradients across …