Response by Heydari et al to Letter Regarding Article, “Effect of Omega-3 Acid Ethyl Esters on Left Ventricular Remodeling After Acute Myocardial Infarction: The OMEGA-REMODEL Randomized Clinical Trial”
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We thank Dr Nägele for his Letter to the Editor and his interest in our work.1 Dr Nägele expressed concern regarding the safety of omega-3 fatty acids based on the numbers of mortality cases in the omega-3 fatty acid and placebo treatment arms. Dr Nägele postulated that the long-term cumulative effect of exposure to omega-3 fatty acids may be harmful because of “lipid peroxidation” following “gradual accumulation within biological membranes.” Although, at the present time, the effects of …