Letter by Nägele Regarding Article, “Effect of Omega-3 Acid Ethyl Esters on Left Ventricular Remodeling After Acute Myocardial Infarction: The OMEGA-REMODEL Randomized Clinical Trial”
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To the Editor:
The investigators of the OMEGA-REMODEL trial (Omega-3 Acid Ethyl Esters on Left Ventricular Remodeling After Acute Myocardial Infarction) report that high-dose omega-3 fatty acid supplementation for 6 months reduces adverse left ventricular remodeling after acute myocardial infarction.1 They conclude that the intervention is safe and that the improvements in cardiac remodeling may translate into significant clinical benefits. The rigorous design of the study with measurement and correlation of dietary response markers significantly adds to the evidence base of dietary and nutritional interventions in cardiovascular disease.
However, although the study was not powered …