Impact of Structural Cerebral Damage in Adults With Tetralogy of Fallot
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Tetralogy of Fallot (TOF) is the most common cyanotic congenital heart disease. Although survival has substantially improved, signs of cerebral damage are still observed in children with surgically corrected TOF.1,2 Potential causes include abnormal fetal brain development, genetic factors, perinatal cerebral injury, increased blood viscosity, and perioperative cerebral damage. In addition, less successful employment is also reported in adults with corrected TOF. It is unclear whether this outcome is because of cognitive impairment caused by cerebral damage.
The present study aimed to investigate cerebral damage in adults with TOF, through structural magnetic resonance imaging (MRI) and neuropsychological examination, and to determine its association with work-related problems. This single-center, observational cohort study was approved by the institutional review board. After providing informed consent, patients underwent a cardiac and cerebral MRI and a brief neuropsychological examination, and they completed a work-related questionnaire. Exclusion criteria were known chromosomal disorders and contraindications for MRI. Cerebral MR images were acquired on a 3.0 Tesla Ingenia scanner (Philips) and evaluated through automated segmentation and …