Response by Saito et al to Letter Regarding Article, “Low-Dose Aspirin for Primary Prevention of Cardiovascular Events in Patients With Type 2 Diabetes Mellitus: 10-Year Follow-Up of a Randomized Controlled Trial”
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We thank Dr Ahmed and colleagues for their comment on our article recently published in Circulation.1 They are very interested in the sex difference in the effect of low-dose aspirin on the primary prevention of cardiovascular events. As they mentioned, earlier studies indicated that low-dose aspirin may be helpful for reducing the risk of stroke in women,2 whereas it may be advantageous for the risk of myocardial infarction in men.2 However, we did not show significant differences between the sexes in the preventive effect of low-dose aspirin in Japanese patients with diabetes mellitus who have no history of cardiovascular diseases. Their major concern was that the effect of aspirin might differ between premenopausal and postmenopausal women.
In our study, we could …