How Useful Are Mouse Models for Understanding Human Atherosclerosis?
Review Examines the Available Evidence
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Animal models are critical for testing new research ideas and bringing them closer to the clinic, but too often observations seen in flies, rodents, and other organisms are later not apparent in humans or are present to a much lesser extent, stripping them of clinical relevance. A new Cell Metabolism review of >9000 publications in the mouse literature indicates that mouse models used for atherosclerosis research may be quite valuable, however, especially for revealing critical processes involved in atherogenesis.
“Over the past 30 years, the vast majority of mechanistic insights into atherosclerosis has come from studies in mice, and so a detailed analysis of the relevance of the findings is clearly important if the results are to be applied to the development of new therapies,” said Aldons J. Lusis, PhD, who is a Professor of Microbiology, Immunology, and Molecular Genetics at the David Geffen School of Medicine at UCLA and is …