Response by Vilahur et al to Letters Regarding Article, “Protective Effects of Ticagrelor on Myocardial Injury After Infarction”
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We thank Drs Downey and Cohen and Dr Fernandez-Jimenez et al for their comments and interest on our article, 1 where we demonstrate in pigs and by 3T-cardiac magnetic resonance (CMR) analysis that ticagrelor protects against myocardial injury to a greater extent than clopidogrel. It is important to note that we report for the first time that ticagrelor cardioprotective effects are associated with the attenuation in myocardial edema formation after myocardial infarction (MI) through adenosine-related mechanisms.
Drs Downey and Cohen have made major contributions to our understanding on the role of antiplatelet agents in cardioprotection by carrying out studies in rabbits and rodents.2,3 In this regard, the discrepancies found between their studies2,3 and Ye et al4 and ours may rely on species-related differences and methodological approaches used. It is worth mentioning that the same group which published the Ye et al4 paper has demonstrated, in contrast with Dr Downey and Cohen’s findings,2,3 that ticagrelor but not clopidogrel …