Response by Sörensen et al to Letters Regarding Article, “Prediabetes and Type 2 Diabetes Are Associated With Generalized Microvascular Dysfunction: The Maastricht Study”
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We appreciate Dr Tsuda and Brzezinski et al for their interest in our study,1 in which we found retinal arteriolar and skin microvascular dysfunction in prediabetes and type 2 diabetes mellitus independent of major cardiovascular risk factors. These findings support the concept that generalized microvascular dysfunction precedes the clinical diagnosis of type 2 diabetes mellitus and may contribute to the development of microvascular complications in (pre)diabetes.
Resting albuminuria has long been favored as clinical biomarker for renal disease and is strongly associated with cardiovascular disease risk.2 An explanation is that albuminuria may reflect generalized (microvascular and macrovascular) endothelial dysfunction.3 Data on the association between direct measures of microvascular dysfunction and albuminuria are, however, scarce. Recently, we have shown an association between capillary …