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Circulation: Arrhythmia and Electrophysiology
Atrioventricular nodal reentrant tachycardia (AVNRT) has not previously been described as a heritable condition. This study analyzed patients who underwent radiofrequency ablation, identifying the occurrence of familial AVNRT defined as presence in at least 2 first-degree relatives. The results of this study are the first to report the prevalence of familial AVNRT, suggesting some degree of heritability.
Familial Occurrence of Atrioventricular Nodal Reentrant Tachycardia
Yoav Michowitz, MD Adi Anis-Heusler, MD Eyal Reinstein, MD Oholi Tovia-Brodie, MD Aharon Glick, MD Bernard Belhassen, MD
Correspondence to: Bernard Belhassen, MD, Department of Cardiology, Tel-Aviv Sourasky Medical Center, Weizman St 6, Tel-Aviv 64239, Israel. E-mail firstname.lastname@example.org
BACKGROUND: Atrioventricular nodal reentrant tachycardia (AVNRT) is considered a sporadic disease occurring in ≈22.5 cases per 10 000 in the general population. We define the prevalence and characteristics of familial AVNRT among patients who underwent radiofrequency ablation.
METHODS AND RESULTS: Ablation reports of all patients with familial AVNRT (at least 2 first-degree family members) who underwent radiofrequency ablation in our institution and in another hospital were reviewed. There were 1587 patients from our institution, of whom 20 had ≥1 first-degree relatives with AVNRT. This indicates a familial AVNRT prevalence of 127 cases per 10 000 (95% confidence interval, 82–196/10 000). First-degree relatives of patients with AVNRT presented a hazard ratio of at least 3.6 for exhibiting AVNRT compared with the general population. After inclusion of 4 families with familial AVNRT who underwent ablation at another hospital our population study comprised a total of 24 families (50 patients) with AVNRT. Patients at ablation were younger in the familial AVNRT group when compared with the sporadic AVNRT group (44.2±19 versus 54.8±18 years old, P=0.0001). The male/female ratio was similar, with female predominance. The supraventricular tachycardia mechanism was typical slow/fast reentry in most cases in both groups. The most common familial relationship in our 24 families included a parent and …