Letter by Wong et al Regarding Article, “Pregnancy and the Risk of Aortic Dissection or Rupture: A Cohort-Crossover Analysis”
To the Editor:
We congratulate Kamel and colleagues1 on their article in Circulation which demonstrated an elevated risk of aortic dissection or rupture during pregnancy in a large cohort of pregnant women. Out of 6 566 826 pregnancies in 4 933 697 women, 36 aortic complications occurred during pregnancy or the postpartum period, with a reassuringly low absolute risk of 5.5 per million patients. Nonetheless, certain aspects warrant further discussion.
As expected, in this study, patients with an underlying connective tissue disease, such as Marfan, Ehler-Danlos, or Turner syndrome, had a 1000-time higher risk of pregnancy-related aortic complications than those without. …