Response by Methawasin and Granzier to Letter Regarding Article, “Experimentally Increasing the Compliance of Titin Through RNA Binding Motif-20 (RBM20) Inhibition Improves Diastolic Function in a Mouse Model of Heart Failure With Preserved Ejection Fraction”
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We thank Lewis and Miller for discussing important questions regarding the possible benefits of Rbm20 inhibition in patients with diastolic dysfunction and, importantly, how to identify those patients who will benefit from titin modification versus antifibrotic therapies. As shown in 2 recent studies1,2 targeting the titin splicing factor Rbm20 can lessen diastolic dysfunction. For example, Methawasin et al1 showed that inhibiting the expression of Rbm20 in a mouse model with a heart failure with a preserved …