The Promise of Cardiac Regeneration by In Situ Lineage Conversion
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Although remarkable advances in acute coronary care have significantly improved outcomes following myocardial infarction (MI), survivors often experience progressive heart failure, a devastating condition with limited curative options. Given that the adult heart cannot regenerate heart muscle cells to restore contractile function, there is great demand to develop therapeutic strategies to build new heart muscle (Figure). Thus, many strategies have been conceived to induce de novo generation of cardiomyocytes for heart repair.
By far the most well-studied approach …