Abstract 20913: Fluid Retention in Elderly Women, Independent of Cardiac and Renal Function in the Community-Based Population
Background: Elderly women is considered to have a higher risk of heart failure with preserved ejection fraction (HFpEF), main pathophysiology of which is a congestion and diuretic-effectiveness in a considerable proportion of patients. Extracellular fluid consists of interstitial fluid and blood plasma, which run throughout the systemic circulation. Multi-frequency bioimpedance analysis (MF-BIA) has enabled us to assess extracellular water (ECW) and intracellular water (ICW), and total body water (TBW) noninvasively. The higher ratio of ECW to TBW (ECW/TBW) has been considered as an indicator of hypervolemia in patients with peritoneal dialysis and cirrhosis. We sought to assess the impact of fluid distribution using MF-BIA in the community-based population.
Methods: We studied 261 community-dwelling subjects without obvious heart diseases (mean age, 67±7 years; 107 men, 154 women) who participated in annual health checkups in a rural Japanese community, Arita-cho. MF-BIA measurements and echocardiography were performed.
Results: ECW, ICW, and TBW were significantly lower in women than in men (14.0+/-1.4 and 10.1+/-1.1L for ECW; 22.3+/-2.4 and 15.8+/-1.6L for ICW; 36.4+/-3.9 and 25.9+/-2.7L for TBW; all for men and women, respectively), and negatively associated with aging (r=0.239, -0.273, and -0.260 for ECW, ICW and TBW, respectively). Conversely, ECW/TBW was higher in women (0.385+/-0.006 and 0.390+/-0.006 for men and women, respectively), and positively associated with aging (r=0.291, p<0.001). Even after adjusted for the presence of hypertension, diabetes, E/e’, left ejection fraction, eGFR, and hemoglobin, higher ECW/TBW was significantly associated with aging and women.
Conclusions: Aging and women are risk factor of fluid retention, independent of cardiac function, renal function, and risk factors for heart failure. This evidence could support diuretic-based management for heart failure with preserved ejection fraction.
Author Disclosures: T. Hasegawa: None. M. Asakura: None. M. Sakamoto: None. H. Asanuma: None. M. Amaki: None. H. Takahama: None. Y. Sugano: None. H. Kanzaki: None. S. Yasuda: None. H. Ogawa: None. T. Anzai: None. M. Kitakaze: None.
- © 2016 by American Heart Association, Inc.