Abstract 20890: Transcutaneous Spinal Cord Stimulation Suppresses Catecholamine-Induced Ventricular Tachycardia via Left Stellate Ganglion Modulation
Introduction: Previous studies indicated spinal cord stimulation could reduce ventricular tachyarrhythmias.
Hypothesis: We examined whether Transcutanenous spinal cord stimulation (TSCS) can prevent epinephrine-induced ventricular tachycardia (VT) in a canine model.
Methods: Sixteen open-chest anesthetized dogs were randomly designed into NSCS group (TSCS plus epinephrine injection, n=8) and control group (sham stimulation plus epinephrine injection, n=8). TSCS was performed for 2 hour before the administration of epinephrine. T-wave alternans (TWA) level, VT prevalence, the VT threshold (according to the dose of epinephrine administered), left stellate ganglion (LSG) function and neural activity were compared between the two groups.
Results: Compared to baseline, TSCS for 2 hour significantly inhibited LSG function and neural activity, whereas no significant change was shown after 2 hour of sham stimulation. Injection of epinephrine resulted in a significant increase in TWA level and LSG neural activity in the control group, which were deceased in the TSCS group. TSCS dramatically decreased VT prevalence and increased VT threshold when compared to the control group.
Conclusions: TSCS could prevent catecholamine-induced VT, possibly by modulating LSG.
Author Disclosures: L. Yu: None. B. Huang: None. X. Zhou: None. H. Jiang: None.
- © 2016 by American Heart Association, Inc.