Abstract 20696: Platelet-Lymphocyte Ratio Predicts Long Term Mortality in Patients Undergoing Coronary Angiography
Introduction: Inflammation and thrombocytosis play an important role in the progression of atherosclerosis and coronary artery disease (CAD). We have previously shown that platelet-lymphocyte ratio (PLR) is an independent predictor of presence of CAD in patients aged 55 years or older. Previous studies demonstrated the association between PLR and cardiovascular prognosis.
Hypothesis: We hypothesize that PLR predicts long term mortality in patients undergoing coronary angiography, regardless of presence of CAD.
Methods: We followed up 525 patients from the BRAVEHEART cohort who were referred for coronary angiography at our institution for a mean period of 5.0±1.3 years. The primary outcome was all-cause mortality. Patients were classified into tertiles based on their pre-angiogram PLR values (<106.3, 106.3-145.6, >145.6).
Results: There were 53 deaths over the follow-up period and patients in tertile3 (PLR>145.6) had worse prognosis compared with patients in tertile1 and tertile2 (29, 12 and 12 deaths respectively, p=0.0046) based on the Kaplan Meier analysis. On multivariate Cox regression analysis, the log PLR was an independent predictor of long term mortality (HR 2.66, 95%CI 1.37-5.15, p=0.004) after adjustment for age, diabetes and history of myocardial infarction.
Conclusion: Higher PLR independently predicts long term mortality in a population of patients undergoing coronary angiograms. Further investigation is warranted to investigate the utility of PLR as a predictive marker of cardiovascular prognosis in larger studies.
Author Disclosures: Y.S. Lee: None. M. Peverelle: None. R. Sultani: None. J. Garlick: None. A.M. Wilson: None.
- © 2016 by American Heart Association, Inc.