Abstract 20644: Association Between Sex Hormones and Ambulatory Blood Pressure
Introduction: Higher levels of free and total testosterone (TT) and lower levels of sex hormone binding globulin (SHBG) have been associated with increased blood pressure (BP) in women with an inverse association between TT and BP reported among men. Fewer studies have examined dehydroepiandrosterone sulfate (DHEAS) or the association between sex steroid hormones and 24-hr ambulatory blood pressure (ABP) or blunted nocturnal BP fall.
Methods: Baseline blood samples were assayed for 267 normotensive racially diverse men (≥50 years) and women (≥55 years) participating in the VITamin D and OmegA-3 TriaL (VITAL). Standardized seated BP (systolic [SBP] and diastolic [DBP]) and 24-hr ABP were measured by trained technicians. All participants provided extensive baseline self-reported data on relevant cardiovascular risk factors and sociodemographic covariates. Linear regression models adjusted for age, sex, race, body mass index, smoking, alcohol, multivitamin use, and fruit and vegetable intake estimated the association between each sex hormone and measures of BP and 24-hr ABP separately by sex. We used logistic regression to estimate (OR, 95% CI) the association between each sex hormone and blunted nocturnal fall, defined as a >10% reduction in SBP or DBP during sleeping hours.
Results: DHEAS, TT and SHBG were not significantly correlated with measures of BP when simultaneously adjusted for one another. In multivariable analyses stratified by sex, among women there was no association observed between sex hormones and measures of BP. Among men, each 10% increase in DHEAS was associated with a 0.45 mmHg increase in seated DBP (β=4.45, 95% CI: 0.71, 8.18) and each 10% increase in TT and SHBG was associated with a 0.67 mmHg (β=-6.73, 95% CI:-11.47, -1.99) and 0.72 mmHg (β=-7.23, 95% CI: -12.05, -2.41) decrease in seated DBP, respectively.
Conclusions: We observed significant inverse cross-sectional associations between DHEAS, TT and SHBG with seated DBP in men, but not SBP, 24-hr ABP or blunted nocturnal BP. There was no association observed between sex hormones and measures of BP among women. Further research is needed to understand how sex hormones may impact BP measures over time.
Author Disclosures: M.C. Jimenez: None. L. Wang: None. J.E. Buring: None. J.E. Manson: None. J.P. Forman: None. H.D. Sesso: None.
- © 2016 by American Heart Association, Inc.