Abstract 20620: The Relationship Between Thyroid-Related Antibodies and Atrial Fibrillation in Euthyroid Patients
Objective: Hyperthyroidism is an important cause of atrial fibrillation (AF). However, the prevalence of thyroid-related antibodies in a normal thyroid function state has not yet been thoroughly documented. Therefore, we aim to identify the relationship between thyroid-related antibodies and AF in euthyroid AF patients compared with age-matched control patients.
Methods: A cross-sectional survey of 1,294 patients (mean age 57.09±14.27 years, 476 males, 818 females) who were euthyroid without anti-thyroid medication was performed. Serum Thyroid- stimulating hormone(TSH) receptor antibodies, anti-microsomal antibodies and anti-thyroglobulin antibody level were measured in 844 non-AF control patients and 450 AF patients using a radioimmunoassay kit.
Results: TSH receptor antibodies were significantly increased in euthyroid AF patients. TSH receptor antibodies were present at 4.23±21.85 u/L and 10.15±45.07 u/L (control vs. AF, respectively; p=0.029). Anti-thyroglobulin antibody levels were 64.31±105.59 u/mL and 71.53±114.51 u/mL (control vs. AF, respectively; p=0.282). Anti-microsomal antibodies were present at 155.53±352.35 u/mL and 198.67±404.50 u/mL (p=0.068, control vs. AF, respectively). Seropositivity was defined as a TSH receptor antibody level exceeding 10 u/L and seropositivity was compared between groups using the chi-square test. In total, 26/569 (4.6%) of control patients and 35/278 (11.2%) of AF patients were seropositive, representing a significant difference (odds ratio, 2.629; p<0.001).
Conclusion: Patients seropositive for TSH receptor antibody were at high risk of AF even when in the euthyroid state.
Author Disclosures: D. Park: None. B. Kim: None. G. You: None. T. Cha: None.
- © 2016 by American Heart Association, Inc.