Abstract 20556: Temporal Trends in Incidence of Malignancy in Patients With Acute Myocardial Infarction Undergoing Percutaneous Coronary Intervention.
Background: Cancer patients are believed to be exposed to increased cardiovascular risk as a result of potential toxicity from radiation and chemotherapy. Beyond traditional risk factors for acute myocardial infarction (AMI), cancer therapies may cause significant injury to the vasculature affecting overall outcomes. We examined temporal trends in incidence of malignancy in patients presenting with AMI requiring Percutaneous Coronary Intervention (PCI).
Methods: Subjects were obtained from the HCUP-Nationwide Inpatient Sample (NIS) database for the years 2002-2013. ICD-9-CM procedure code were used to identify patients with Genitourinary, Gastrointestinal, Pulmonary, Skin, Breast and Hematologic malignancies treated with PCI for AMI.
Results: Among 3,445,430 patients undergoing PCI for AMI during the study period, 236,101 (6.9%) had a history of malignancy. Genitourinary cancer was the most prevalent type increasing by 55.4% over the twelve-year period from 2.05% of the cases in 2002 to 3.18% in 2013. The highest increase, 160.2%, was observed in Skin cancer; incidence from 0.51% of the cases in 2002 to 1.33% in 2013, followed by Hematologic malignancies, 86.3% increase, from 0.56% of the cases in 2002 to 1.04% in 2013. Incidence of Gastrointestinal, Pulmonary and Breast malignancies were also elevated by 38.5%, 64.6% and 41.3% respectively. The reported increase in the incidence of malignancy was statistically significant in all subtypes over the years (P<0.001). (Figure 1)
Conclusion: Hospital admissions for cancer patients presenting with AMI and requiring PCI increased significantly in the US during the last twelve years. Genitourinary malignancies are the most frequent subtype, while skin malignancies are the fastest increasing one.
Author Disclosures: K.V. Voudris: None. M.I. Vidovich: None.
- © 2016 by American Heart Association, Inc.