Abstract 20475: The Addition of Dietary Probiotics to the DASH Diet: A Novel Intervention on Human Glycemic State
Introduction: Recent studies have demonstrated an association between the composition of an individual’s gut microbiota and their cardiovascular risk. Preliminary studies in animal models have suggested that supplementing gut flora with probiotics can reduce blood sugar profiles. The purpose of this study was to determine the impacts of supplementing the DASH diet with dietary probiotics on blood sugar profiles of essential hypertensives.
Methods: 80 stable essential hypertensives from a single hypertension clinic were recruited. All participants had measurements of Haemoglobin A1C and fasting blood sugar before and after a three month dietary intervention period. Patients were randomized into one of two groups and counseled on the control, standard-of-care DASH diet, or a dietary probiotic enriched version of the DASH diet termed the “Pro-DASH” diet depending on their random group allocation.
Results: At baseline, there was no statistically significant differences between the groups for any demographics or measured values. Reductions in both Haemoglobin A1C and in Fasting Blood Sugar were noted in both the control DASH diet group and the probiotic enriched diet intervention group. The control DASH diet group had an average 3.4% reduction in Haemoglobin A1C compared to 8.9% in the probiotic intervention group (p<0.001). Similarly, the probiotic enriched intervention group had an average 10.7% reduction in fasting blood sugar in comparison to a 3.3% reduction in the control group. Similar improvements were noted in a sub-group of pre-diabetic metabolic syndrome patients.
Conclusions: The overall results of this study appear to suggest that augmenting the DASH diet with probiotics may improve blood sugar in essential hypertensives. A potential mechanism that should be further explored is the interaction between probiotics and the compound butyrate which is generated by specific gut bacteria and which has been shown to impact insulin sensitivity. If the results of this study are validated in larger and more diverse patient populations over a longer period of time, then supplementing traditional dietary approaches with probiotics could represent a significant advancement in the nutritional management of prevention of diabetes.
Author Disclosures: A.K. Pandey: None.
- © 2016 by American Heart Association, Inc.