Abstract 20420: The Effect of High Intensity Aerobic Exercise Training over Two Years on Biologic Aortic Age
Introduction: Lifelong exercise training maintains youthful compliance of the central arteries. The exact mechanism by which lifelong aerobic fitness confers cardiovascular benefit is unknown. Aortic age, a measure of the intrinsic stiffening of the central arteries, is one means by which changes in arterial function can be quantified. Prior training studies in seniors have shown minimal improvement in biologic aortic age. Additionally, middle age may represent a life period in which vascular plasticity still exists. We hypothesized, therefore, that aortic age would decrease after a 2 year high intensity aerobic training program (HAT) in previously sedentary middle age adults.
Methods: Sixty one sedentary, healthy middle-aged subjects were randomized to either yoga or HAT (2 moderate aerobic exercise sessions/week and 2 “4x4” aerobic interval sessions/week) for 2 years. Four subjects in the yoga group and 5 in the exercise group withdrew prior to completion of the study. Aortic age was not analyzable in 2 subjects. Aortic age was calculated from Modelflow reconstruction of the finger blood pressure waveform (BMEYE) and stroke volume (acetylene foreign gas re-breathing method) at baseline and post-intervention.
Results: Adherence to prescribed exercise sessions in the HAT group over 2 years was 90%. After 2 years, aortic age increased with a mean of 5.7 years in the yoga group, and remained relatively unchanged in the HAT group (p < 0.19).
Conclusions: High intensity aerobic training over 2 years slowed but did not significantly decrease aortic age in sedentary adults. These results suggest that while reversal may not be achieved with exercise, retarding further aortic aging may be possible.
Author Disclosures: W.A. Omar: None. S. Sarma: None. E. Howden: None. M. Samels: None. B. Everding: None. S. Livingston: None. D. Palmer: None. B. Levine: None.
- © 2016 by American Heart Association, Inc.