Abstract 20349: Left Ventricular Diastolic Dysfunction and Obstructive Sleep Apnea in a Large Middle-Aged Asymptomatic Population
Introduction: The diagnosis of obstructive sleep apnea (OSA) has been increasing through the years due to better patient and physician awareness and education. We know that OSA is associated with left ventricular diastolic dysfunction (LVDD) as well as cardiovascular events. We aim to describe the relationship between LVDD, and OSA risk as compared to OSA diagnosis.
Methods: Analysis was performed on 940 participants enrolled in the World Trade Center (WTC)-CHEST program. Participants underwent an echo Doppler study to evaluate peak mitral inflow velocities at early (E) and late (A) diastole, transmitral E/A ratio and Tissue Doppler Imaging (TDI) of the left ventricular (LV) septum in the apical four-chamber view. LVDD is computed by the JASE 2009 guidelines and Left Ventricular index (LVindex) as defined by JASE 2015 guidelines. High risk for OSA (OSA+) was identified as 2 or more positive categories from the Berlin Questionnaire (BQ) and diagnosis of OSA was patient reported physician diagnosis (OSAdx). We performed chi-squared, independent T-test and ANOVA.
Results: Of the 940 participants enrolled, 27.23% (256) are OSA+ and 27.77% (261) are OSAdx. Those with OSA+ and OSAdx were significantly more likely to have LVDD (p=0.0181 and p=0.0085, respectively). LVindex trended toward a significant association with OSA+ (p=0.0572, OR=1.012, 95% CI [1.000-1.025]). LVindex was significantly higher in those who were diagnosed with OSA compared to those who were low risk for OSA, with mean LVindex of 84.22 vs 76.12 (p=0.0247).
Conclusions: Those with diagnosis of OSA and high risk for OSA identified by the BQ are more likely to demonstrate LVDD on echocardiogram. Patients who are identified as high risk for OSA using the BQ would benefit from evaluation of left ventricular function in order to initiate strategies to prevent heart failure with preserved ejection fraction (HFpeF)
Author Disclosures: R.L. Iyengar: None. C. Maceda: None. J. O’Boyle: None. M. McLaughlin: None.
- © 2016 by American Heart Association, Inc.