Abstract 20342: Ageing-Induced Elevation in Circulating C1q Level is Associated With Arterial Stiffness
Introduction: Aging reduces muscle mass and elevates the risk of developing cardiovascular disease. Aging-induced muscle loss is related to muscle fibrosis, and a molecular mechanism of muscle fibrosis contributes to an activation of canonical Wnt signaling pathway via C1q. In our recent study, serum C1q level was increased with advancing age and was negatively correlated with muscle mass in elderly adults. Alterations in arterial structure and function occur with advancing age, such as decrease elastic fiber, decline in endothelial function and increase in arterial remodeling and stiffness. Recent study reported that C1q contributed to arterial remodelling in mice. However, the association between circulating C1q levels and arterial stiffness in human remains unclear.
Purpose: This study aimed to clarify whether aging-induced increase in serum C1q level is a risk factor of cardiovascular disease in a cross-sectional study.
Methods: One-hundred thirty one healthy subjects (18-81 years, male: n=69, female: n=62) were enrolled in this study. All subjects were divided into two groups; young (<40 year) and middle-aged and older (≥40 year) groups. Serum C1q, TNF-alpha, IL-6 concentrations were determined by ELISA. Systemic arterial stiffness was estimated by using brachial-ankle pulse wave velocity (baPWV).
Results: Serum C1q, TNF-alpha and IL-6 levels and baPWV was significantly higher in middle-aged and older group compared with young group (respectively p<0.05). Additionally, the serum C1q level was positively correlated with baPWV in both male (r=0.44, p<0.05) and female (r=0.61, p<0.05). Furthermore, serum TNF- alpha level was positively correlated with baPWV in only female (r=0.42, p<0.05), and serum IL-6 level was positively correlated with baPWV in only male (r=0.29, p<0.05). After adjusting for 12 confounders (sex, %fat, blood pressures, serum TNF- alpha and IL-6 levels, fasting blood glucose and lipid profiles), the association between the serum C1q level and baPWV remained statistically significant (ß=0.29, p<0.05).
Conclusions: These results suggest that aging-induced elevation in serum C1q level may be a risk factor of cardiovascular diseases, i.e., arterial stiffness.
Author Disclosures: N. Hasegawa: None. S. Fujie: None. N. Horii: None. K. Sanada: None. T. Hamaoka: None. M. Iemitsu: None.
- © 2016 by American Heart Association, Inc.