Abstract 20310: Excess All-Cause and Cardiovascular Morbidity Associated With Overweight and Obesity: Findings From the Chicago Heart Detection Project in Industry Study
Background: We sought to determine the association of body-mass index (BMI) in younger adulthood with life lived free of morbidity and cumulative burden of all-cause and cardiovascular (CV) morbidity through older adulthood.
Methods: Participants (N=25,930) from the Chicago Heart Association (CHA) study, a longitudinal cohort of employed men and women recruited from 1967-1973, ages 18-59 years at baseline were included. Linked CMS/NDI data from 1984-2010 were used to determine morbidity after age 65 from all participants enrolled in Medicare. Individuals were classified by BMI at baseline and analyses were adjusted for age, sex, race, education, smoking, hypertension, hyperlipidemia, and diabetes. All-cause morbidity was defined using the Gagne score. A CV morbidity score was defined as the sum of coronary heart disease, peripheral vascular disease, stroke, and heart failure diagnoses.
Results: Participants were 41% female and 8% African American; mean age was 43±11 years. Two percent were underweight, 43% had normal BMI, 42% were overweight, 13% were obese, and 0.5% were morbidly obese. Overweight, obese, and morbidly obese persons had earlier onset of all-cause morbidity (Figure) by 1.1, 2.8, and 5.5 years, respectively, and reduced overall survival by 0.7, 2.2, and 5.9 years, respectively, resulting in a greater proportion of life lived with morbidity. Compared to those with normal BMI, all participants with excess weight (overweight, obese, and morbidly obese) had greater levels of adjusted all-cause and CV morbidity from age 65-90 years, and a higher cumulative morbidity burden.
Conclusions: Younger adults with excess weight, even overweight, in young adulthood live a shorter life with a greater burden of all-cause and CV morbidity after age 65. These findings highlight the adverse effects of overweight, obesity, and morbid obesity beginning in young adulthood and stress the importance of maintaining ideal body weight for greater and healthier longevity.
Author Disclosures: S.S. Khan: None. D.M. Lloyd-Jones: None. L. Zhao: None. L. Liu: None. M. Daviglus: None. K. Liu: None. J.F. Fries: None. T. Shih: None. D. Garside: None. T. Vu: None. J. Stamler: None. N.B. Allen: None.
- © 2016 by American Heart Association, Inc.