Abstract 20256: Exposure to Heavy Metals Linked to Increased Left Ventricular Mass and Abnormal Geometry
Introduction: First Responders working at Ground Zero following the 9/11 tragedy were exposed to particulate matter including heavy metals. Heavy metals such as cadmium (Cd) and lead (Pb) are not readily excreted by the body and elevated levels have been noted post exposure. Cadmium exposure has been associated with increased risk of stroke, heart failure, and cardiovascular mortality. Lead exposure is known to affect cardiac function. Given the high levels of exposure to particulate matter at Ground Zero this study seeks to evaluate the cardiac morphology of First Responders with elevated blood and urine levels of Cd and Pb.
Methods: We evaluated 347 enrolled first responders from the World Trade Center-RENAL Program. Participants received a complete echo Doppler study. LV geometry was determined by relative wall thickness (RWT) and LV mass index (LVmi). Concentric hypertrophy was defined as elevated RWT and LVmi, eccentric hypertrophy defined by elevated LVmi with normal RWT and concentric remodelling defined as elevated RWT with normal LVmi, per 2015 American Society of Echocardiography guidelines. We measured blood and urine levels of Cd and Pb.
Results: We demonstrated a significant relationship between LV geometry and urine Pb, urine Cd and blood Cd (p=0.0019, p=0.0211 and p=0.0372). Participants with the highest levels of heavy metal had the most abnormal LV geometry.
Conclusions: Detection of urine Pb, urine Cd and blood Cd is significantly associated with abnormal LV geometry. This correlation suggests those with exposure to heavy metals are at risk for cardiac dysfunction and future studies should aim towards further understanding this relationship.
Author Disclosures: J. O’Boyle: None. R.L. Iyengar: None. A. Sahota: None. C. Maceda: None. C. Wyatt: None. M. McLaughlin: None.
- © 2016 by American Heart Association, Inc.