Abstract 20165: Dynamics Mechanical Strains of Tricuspid Valve Septal Leaflets
Introduction: Tricuspid valve (TV) regurgitation is a common valvular disease, which may require valvular repair or replacement. A better understanding of the TV biomechanics during the cardiac cycle could lead to more efficient treatment strategies for TV regurgitation. The purpose of this study was to establish a framework for the measurement of the deformation of TV leaflets in a passive ex-vivo beating heart that mimicked the right ventricular dynamic pressure of the normal hearts.
Methods: The apexes of fresh porcine hearts (n= 8) were connected to a positive displacement pump (SuperPump AR Series, Vivitro Labs Inc., BC) to generate pulsatile flow in the right side of the hearts. The superior vena cava was conected to a reservoir as the inflow pathway and the pulmonary artery was used for the outflow pathway. Pressure probes (SPR-524 and PCU-2000, ADInstruments, Colorado Springs, CO) were used to record transient pressure at the right atrium, pulmonary artery, and the right ventricle. Sixteen sonomicrometry crystals were sutured to the TV septal leaflet, TV annulus, and the apex of the hearts to record the leaflets deformation. All the data were acquired using a sonomicrometer device (TRX Series 16, Sonometrics Co., ON) with a frequency of 100 Hz.
Results: The positional data from the sonomicrometry crystals were used to calculate the areal, maximum principal, circumferential, and radial strains over the entire cardiac cycle. The maximum principal strain of 11.2 ± 1.5 % (mean ± standard error) was obtained at maximum right ventricular pressure (Figure 1), similar to the in-vivo strain values of the mitral valve.
Conclusions: Overall, our new experimental setup provided repeatable pressure and strain measurements. Our technique can be further modified to investigate changes in the leaflet deformation due to valvular lesions (e.g. chordae rupture) or surgical interventions (e.g. leaflet resection) in fresh animal and/or cadaverous human hearts.
Author Disclosures: K. Amini Khoiy: None. D. Biswas: None. T.N. Decker: None. K.T. Asgarian: None. F. Loth: None. R. Amini: None.
- © 2016 by American Heart Association, Inc.