Abstract 20158: Vitamin D Supplements Do Not Reduce Depressive Symptoms and Cardiac Events in Depressed Patients With Heart Failure
Introduction: Vitamin D deficiency is commonly observed in heart failure (HF) patients. Depressive symptoms do not predict shorter cardiac event-free survival in HF patients with vitamin D adequacy, but it is unknown whether vitamin D supplements reduce depressive symptoms and cardiac events.
Purpose: To examine the impacts of vitamin D supplements on depressive symptoms and cardiac event-free survival in HF patients.
Methods: HF patients with a Patient Health Questionnaire- 9 (PHQ-9) score ≥ 5 completed a 3-day food diary to determine average daily intake of vitamin D. Patients were divided into 2 groups by the recommended daily intake of vitamin D of 10 mcg until age 64 and 15 mcg for patients aged 65 and over. The PHQ-9 was used to reassess depressive symptoms at 6 months. Data on cardiac events for up to 1 year, prescribed medications, and vitamin D supplements were obtained from patient interview and review of medical records. Depressive symptoms at 6 months and cardiac event-free survival compared using hierarchical linear and Cox regressions.
Results: A total of 125 patients had depressive symptoms indicating a PHQ-9 score ≥ 5. The average intake of vitamin D was 5.8±4.1 mcg/day and 49 patients (39%) had vitamin D deficiency. Fifty-eight patients (46%) were taking vitamin D supplements. Patients were grouped by vitamin D adequacy or deficiency and use of vitamin D supplements (yes or no). In hierarchical linear regression, patients with vitamin D deficiency and no supplements were associated with increased depressive symptoms at 6 months (β=0.438, p< .001) and showed the shortest cardiac event-free survival (p= .009) among 4 groups in hierarchical Cox regression.
Conclusions: Vitamin D deficiency was associated with higher risk for depressive symptoms and shorter cardiac event-free survival in HF patients regardless of vitamin D supplements. Ongoing assessment for vitamin D intake is necessary for depressed patients with HF, even when they take vitamin D supplements.
Author Disclosures: E. Song: Research Grant; Modest; This work was supported by a grant, NRF-2015R1D1A1A01059392 from the National Research Foundation of Korea. D.K. Moser: None. T.A. Lennie: None.
- © 2016 by American Heart Association, Inc.