Abstract 20116: The Majority of Patients Presenting With Symptomatic Peripheral Artery Disease Report Atypical Symptoms Findings From the PORTRAIT Registry
Introduction: Peripheral artery disease (PAD) is associated with high rates of mortality and adverse cardiovascular outcomes but can be difficult to diagnose, particularly with atypical symptoms. We sought to identify patient characteristics associated with atypical, as compared with classic, claudication in patients presenting to PAD specialty clinics.
Methods: From the international PORTRAIT registry, 778 consecutive patients presenting to specialty PAD clinics with confirmed PAD (ABI ≤ 0.90) between 06/2011 and 02/2015 completed the San Diego Claudication Questionnaire (SDCQ). Patients were classified as having typical (exertional pain in calves relieved within 10 minutes of resting) or atypical claudication. A hierarchical, multivariable logistic regression model was created to predict atypical symptoms based upon patients’ clinical characteristics.
Results: A total of 541 (70%) patients had atypical claudication. Younger age, greater BMI, not having diabetes and better Peripheral Artery Questionnaire (PAQ) physical limitation scores (Figure) were associated with atypical symptoms. Both groups had a similarly high prevalence of cardiovascular risk factors.
Conclusions: The majority of patients presenting with new or worsening PAD symptoms do not report typical claudication symptoms on the SDCQ. Patients with PAD presenting with atypical symptoms are typically younger, heavier, non-diabetic, and present with less physical limitations than patients with typical claudication symptoms. Better understanding the response to treatment in patients with atypical symptoms is needed.
Figure: Abbreviation: GAD = General anxiety disorder; PAQ = Peripheral Artery Questionnaire.
Source of Funding: Research reported in this work was funded through a Patient-Centered Outcomes Research Institute (PCORI)
Author Disclosures: T.A. Hammad: None. P.G. Jones: None. K.G. Smolderen: Research Grant; Significant; Patient-Centered Outcomes Research Institute. J.A. Spertus: Research Grant; Modest; American College of Cardiology Foundation, Lilly. Honoraria; Modest; Amgen, Copyright for SAQ, KCCQ and PAQ, Janssen, Novartis, Regeneron, United. Consultant/Advisory Board; Modest; Healthcare Scientific Advisory Board; Ownership Interest Interest/Partnership Principal - Health Outcomes Sciences;. M.R. Patel: Consultant/Advisory Board; Significant; MP is a member of the Janssen and Bayer Advisory Boards. H.D. Aronow: None. M.H. Shishehbor: None.
- © 2016 by American Heart Association, Inc.