Abstract 20080: Health Status Profiles in Patients Presenting for Specialty Care With New Versus Worsening Symptoms of Peripheral Arterial Disease: Insights From the PORTRAIT Study
Introduction: Peripheral arterial disease (PAD) symptoms are associated with impairment in ambulatory function and overall quality of life (QOL). However, no data exist on PAD-specific health status profiles in patients with new or an exacerbation of PAD symptoms seeking treatment at a PAD specialty clinic.
Methods: Data on 798 patients with new or an exacerbation of PAD symptoms were collected from 10 US PAD specialty clinics (June 2011 and October 2015) in the PORTRAIT study. Mean Peripheral Arterial Questionnaire (PAQ) and EQ-5D scores were tracked upon PAD evaluation and, 3 and 6 months thereafter. We examined whether health status scores differed by new versus worsening symptoms of PAD using repeated measures analyses, adjusting for age and sex.
Results: Patients with new onset symptoms of PAD (n= 321, 40.2 %) were younger, less often had dyslipidemia and had higher ankle brachial index values. Importantly, no differences in Rutherford classification or type of primary PAD treatment (invasive vs. non-invasive) were noted across groups. In the overall group, there was improvement in all PAQ and EQ5D scores during 3- and 6-month follow up (p-values <.0001). For the PAQ summary, symptoms, and QOL scale, improvements up to 1 standard deviation (SD) were noted; less than 1 SD improvement was observed for the EQ-5D scale (Table). Age- and sex-adjusted mean health status scores were not different between those with new-onset vs. an exacerbation of symptoms. Over time, patients’ health status for both groups improved at a similar rate (interaction time*new or worsening of symptoms not significant).
Conclusions: Overall, patients with a recent diagnosis of PAD have a severely impaired health status, but rapidly improve after seeking PAD specialty care, regardless whether patients present with new or an exacerbation of symptoms. These insights can be used to better inform clinicians and patients with PAD as to what can be expected with regards to patients’ health status patterns.
Author Disclosures: M. Omer: Other; Modest; Research reported in this wrok was funded through a Patient-Centered Outcomes Research Institute (PCORI) Award (CE-1304-6677). M. Qintar: Other; Significant; supported by the National Heart, Lung, and Blood Institute of the National Institutes of Health under Award Number T32HL110837.. F. Tang: None. J. Spertus: Research Grant; Modest; NHLBI, AHA, ACCF, Lilly, Gilead. Honoraria; Modest; United Healthcare, Novaratis, Amgen, Bayer. Ownership Interest; Significant; Health Outcomes Sciences, the commercial entity distributing and supporting ePRISM,, Owns copyrights to the Seattle Angina Questionnaire. K. Smolderen: Research Grant; Significant; Patient-Centered Outcomes Research Institute.
- © 2016 by American Heart Association, Inc.