Abstract 20079: Cardioprotective Medications and Quality of Life in Peripheral Arterial Disease: Insights From Q-PAD Registry
Introduction: Peripheral arterial disease (PAD) has a high prevalence with increasing incidence over the last decade. The great majority of patients have co-morbidities that require them to be on cardioprotective (CP) medications. These medications (beta-blockers, ACEI/ARBS, CCB, Statins) have been shown to decrease morbidity and mortality. However, the effect of these medications on the patients’ quality of life (QOL) after percutaneous vascular intervention (PVI) has not been well studied.
Methods: We conducted a retrospective study to evaluate the effects of CP medications on QOL (1-6 months) post-PVI in patients with PAD. We evaluated a total of 344 patients after we divided them into 3 groups depending on the number of CP medications they are taking. Group 1 included only patients on dual anti-platelets therapy (DAPT). Group 2 included DAPT plus only one of CP medications. Group 3 included DAPT and at least two of the CP medications. The Peripheral Arterial Questionnaire (PAQ) was used to evaluate QOL at baseline then at follow-up (1-6 month post-PVI).
Results: All 3 groups had similar PAQ scores at baseline and showed improvement at the follow-up PAQ scores. Being on more CP medications, was associated with more improvement in quality of life, however, this did not reach statistical significance.
Conclusion: There was a trend for PAD patients, who were on more CP medications at the time of discharge following PVI, to have a better overall QOL. However, this improvement was not statistically significant as compared to the other groups with fewer medications. This could be explained by the fact that the medications were studied as one group while different classes of CP medications might have different effects on symptoms of PAD and thus quality of life.
Author Disclosures: A. Zaitoun: None. S. Al-Najafi: None. T. Musa: None. S. Szpunar: None. D. Light: None. H. Yamasaki: None. T. Lalonde: None. R.H. Mehta: None. H.S. Rosman: None.
- © 2016 by American Heart Association, Inc.