Abstract 20053: Ps100 Helps Predict Neurological Statue for Ecpr Patient ?
Introduction: Prognostication for cardiac arrest requires time.Neuroproteins can help prognosticate neurological outcome. Early prognostication for patients treated by ECPR could help identify those with poor neurological prognosis in order to consider termination of care or organ donation.
Hypothesis: Our objective was to investigate the prognostic value of S-100 protein in patients treated by ECPR for refractory cardiac arrest (RCA).
Methods: We conducted a retrospective single center observational study during 17 months. We included patients presenting a RCA treated by ECPR. All patients admitted had daily blood samples (day 1 to day 4) in order to evaluate S100 protein. Patients were separated into 2 groups according to their neurological outcome at ICU discharge: favorable outcome (CPC 1-2) and unfavorable outcome (CPC 3-5). We compared mean daily S-100 protein concentrations for these 2 groups using a Student T test.
Results: During the study period, 37 patients were included; 13 were discharged with favorable neurological outcome. Mean daily S-100 protein concentrations are shown in table 1 and figure 1. On days 2 and 3, mean S-100 protein values were significantly lower in patients with favorable outcome
Conclusions: S-100 protein can help prognosticate neurological outcome in patients treated by ECPR for RCA, as early as day 2 (i.e. before they can be clinically evaluated). Non significance for day 1 results from lack of statistical power. Further investigations are needed to confirm these results and determine a threshold value above which no favorable outcome can be expected. This is particularly interesting for the early identification of potential organ donors.
Author Disclosures: A. Hutin: None. B. Hammadi: None. R. Jouffroy: None. C. Dagron: None. K. An: None. J. Beaudeux: None. P. Carli: None. L. Lamhaut: None.
- © 2016 by American Heart Association, Inc.