Abstract 20048: Carbon Nanotube Fibers Restore Myocardial Conduction In Vivo
Introduction: Reduced myocardial conduction velocity (MCV) is pathologic and may be associated with conduction block and ventricular tachycardia. No anti-arrhythmic treatment exists that restores MCV. Recently, we described carbon nanotube fibers (CNTf) as an electrically conductive, strong, flexible, and fatigue-resistant material with potential in biomedicine.
Hypothesis: CNTf sewn across epicardial scar can improve myocardial conduction to baseline.
Methods: Three anesthetized sheep received left lateral thoracotomy to expose the left lateral ventricular epicardium. Four decapolar catheters were placed in a 10x10 cm box configuration on the left lateral ventricle, and pacing fibers were implanted in the center. Baseline recordings of myocardial conduction velocity from central LV pacing were performed and then a horseshoe-shaped ablation scar was created on the left ventricle, creating a peninsula of perfused tissue with prolonged conduction times.
Results: At baseline, mean ventricular myocardial conduction time from pacing leads to decapolar catheters was 26.5 ± 1.7 msec. RF ablation resulted in significant increase in conduction time at scar apex to 36.8 ± 1.1 msec (P<0.001). After surgical CNTf implantation at scar apex, mean conduction time improved to 29.3 0.8 msec (P<0.001) and was similar to the baseline non-scarred condition (P=1). By comparison, silk suture negative control showed no significant improvement in conduction time vs. scarred condition (P=1).
Conclusions: We have shown a novel strategy to acutely restore MCV in scarred myocardium based on flexible, strong, conductive CNTf. In vivo electrophysiology studies in an ovine model of delayed conduction caused by an anatomical block (RF-created scar) showed that conductive CNTf sutures can significantly decrease conduction time to near baseline values. Future studies will examine how improvement in conduction velocity may reduce scar-related risk of ventricular reentry.
Author Disclosures: M.D. McCauley: Ownership Interest; Modest; Nanolinea, Inc. F. Vitale: Ownership Interest; Modest; Nanolinea, Inc. C. Young: Ownership Interest; Modest; Nanolinea, Inc. M. Pasquali: Ownership Interest; Modest; Nanolinea, Inc. M. Razavi: Ownership Interest; Modest; Nanolinea, Inc..
- © 2016 by American Heart Association, Inc.