Abstract 19800: 18F-FDG PET/CT in the Diagnosis and Management of Continuous Flow Left Ventricular Assist Device Infections: The Rotterdam Experience
Introduction: Infections in left ventricular assist devices (LVAD’s) are associated with high mortality and morbidity. Unfortunately, differentiating between deep and superficial infections could be very cumbersome. In this case series, we describe our single center experience using 18F-FDG PET/CT in the diagnosis and management of LVAD infections.
Methods: Between 2011 and 2016, we reviewed all consecutive HeartMate II (n=51) patients in our tertiary referral center. 18F-FDG PET/CT was done in 9 patients (7 males; mean age 53 ± 15 years) with suspected LVAD infections.
Results: The median duration of LVAD support was 134 days [range 24-645 days] before 18F-FDG PET/CT was performed. The mean age was 54 ± 15 years with 78% males. The primary indications for LVAD implantation were bridge-to-transplant (8/9) and destination therapy (1/9). Nine patients with suspected LVAD infection, either pump or driveline with 33% has positive blood cultures, 44 % had positive wound cultures. In 33% we performed the 18F-FDG PET/CT at short term (within 90 days postoperative) and in 67% the 18F-FDG PET/CT was performed at longer term follow-up. In all, 18F-FDG PET/CT was performed to establish and determine the extent of LVAD infections, within 67% there were unexpected extensive deep infections. In 2/9 patients, 18F-FDG PET/CT could rule out any LVAD infections, both very early (24 and 29 days) in the postoperative phase.
Conclusions: In this case series of nine LVAD patients, 18F-FDG PET/CT imaging differentiated excellently between deep and superficial LVAD infections as earlier as 3 weeks post-implantation.
Author Disclosures: S. Akin: None. R. Muslem: None. A.A. Constantinescu: None. O.C. Manintveld: None. O. Birim: None. J.J. Brugts: None. A.P. Maat: None. A.C. Fröberg: None. A.J. Bogers: None. K. Caliskan: None.
- © 2016 by American Heart Association, Inc.