Abstract 19460: Obesity Associates With Heart Failure in Young Adults With Congenital Heart Disease
Introduction: Adults with Congenital Heart Disease (ACHD) are a growing segment of the population, at elevated cardiovascular risk. This risk increases with age, and is primarily attributable to congestive heart failure (CHF). Obesity is an emerging cardiovascular risk factor, associated with CHF in the healthy adult population. To date, however, the relationship between obesity and CHF in ACHD is poorly described.
Hypothesis: We hypothesized that obesity would independently associate with CHF in young ACHD.
Methods: Retrospective analysis was performed on all ACHD (identified via ICD-9 coding), ages 19 - 45 years old, seen at a Pediatric Heart Network-affiliated center in 2013. ACHD were classified as having simple or complex congenital heart disease per the Bethesda Conference Criteria. Obesity was defined as body-mass index ≥ 30 kg/m2. Statistical analysis included multivariate regression and likelihood ratio testing.
Results: 493 ACHD met inclusion criteria, with 24 identified cases of CHF. CHF patients had a higher prevalence of obesity (p=0.003), diabetes (p <0.001), and hypertension (p=0.05), as compared to patients without CHF (Table 1). Logistic regression analysis revealed that obese ACHD had greater odds of having CHF (OR 3.29, p <0.01) than non-obese ACHD, which retained significance beyond adjustment for traditional cardiovascular risk factors and complex/univentricular congenital heart disease (OR 2.66, p=0.03) (Table 2). Likelihood ratio testing revealed that obesity independently predicted the odds of having concomitant CHF (X2 4.49, p=0.03), a finding not seen in hypertension, hyperlipidemia, or diabetes mellitus.
Conclusions: Obesity was independently associated with CHF in this cohort of 493 young ACHD. In the midst of the modern obesity epidemic, these results may indicate a need for improved lifestyle counseling in congenital heart disease patients of all ages. Larger, prospective studies are needed to confirm these findings.
Author Disclosures: J.B. Lerman: None. I.A. Parness: None. R.U. Shenoy: None.
- © 2016 by American Heart Association, Inc.